Casco Viejo, the Old Quarter, in Panama is a unique walled city. It consists of 16th and 17th Century Spanish Colonial Architecture.
This neighborhood is a melting pot of many cultures and home to the Presidential Palace. In addition, there are restaurants, boutiques and charming buildings surrounding the plazas as well as manicured gardens.
Street vendors in this area sell everything from empanadas to raspao (snow cone) to cool you down on a hot day. Stay at a nearby hotel or rent an apartment for extended stays. More information is here.